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Secure prescription printing is a challenge faced by hospitals and health systems across the United States. In every state, hospitals and health systems are required to meet Centers for Medicare & Medicaid Services (CMS) compliance standards for secure prescription printing. Most states have approved prescription printing on plain paper. However, a handful of states still require prescriptions to be printed on preprinted paper stock. No matter what the state requirements, hospitals and health systems need to secure their prescription printing either by protecting their preprinted paper stock, or by creating a process that ensures tamper-resistant prescription printing on plain paper.